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Filtered Search Results
AURUM PHARMATECH INC TERT-BUTYL N-METHYL-N-CARBA 1G
NC3454432 TERT-BUTYL N-METHYL-N-CARBA 1G
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eMolecules 5622-36-6 | methyl 2-(quinolin-6-yl)acetate | Pharmablock - Stock | MFCD04038669 | 201.225 | C12H11NO2 | 97.000 | COC(=O)Cc1ccc2ncccc2c1 | 5g | 415696919
methyl 2-(quinolin-6-yl)acetate | Pharmablock - Stock | 5622-36-6 | MFCD04038669 | 201.225 | C12H11NO2 | 97.000 | COC(=O)Cc1ccc2ncccc2c1 | 5g | 415696919
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Apexbio Technology LLC SCH 527123 473727-83-2 200mg
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SCH 527123 (CAS 473727-83-2) is a selective antagonist of chemokine receptor 2 (CXCR2) It inhibits CXCR2-mediated signaling pathways by reducing phosphorylation events within the NF- B MAPK and AKT signaling cascades In colorectal cancer cell lines SCH 527123 suppresses cell growth in a dose-dependent manner with reported IC50 values ranging from approximately 18 to 40 mol/L after a 72-hour treatment Elevated IL-8 expression in cell lines such as HCT116 and Caco2 correlates with decreased sensitivity to SCH 527123 This compound is utilized in research investigating CXCR2 signaling in inflammation and tumor growth
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Apexbio Technology LLC LKB1 (AAK1 dual inhibitor) 1093222-27-5 200mg
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LKB1 (AAK1 dual inhibitor CAS 1093222-27-5) is a selective inhibitor targeting both LKB1 kinase and adaptor-associated kinase 1 (AAK1) These kinases are serine/threonine protein kinases implicated in cellular metabolism polarity and endocytic trafficking pathways respectively By simultaneously inhibiting LKB1 and AAK1 activity this small molecule modulates diverse intracellular signaling cascades associated with cell proliferation and membrane trafficking Due to these mechanistic features LKB1 (AAK1 dual inhibitor) serves as a valuable research tool for studying kinase-associated pathways in various biomedical contexts and potentially informing therapeutic strategies
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Apexbio Technology LLC 17-AAG (KOS953) 75747-14-7 200mg
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17-AAG (KOS953) is a synthetic derivative of geldanamycin that inhibits heat shock protein 90 (HSP90) It acts by binding to HSP90 causing destabilization of client proteins including HER2 Raf-1 p53 and components of MAPK signaling pathways Reported IC50 for 17-AAG in BT474 cells is approximately 6 nM Its biological activity has been investigated broadly including in multiple myeloma breast cancer thyroid cancer Hodgkin lymphoma and melanoma cellular models Ongoing studies explore 17-AAG both as monotherapy and in combination with agents like bortezomib or trastuzumab for addressing treatment-resistant cancer cell lines Currently 17-AAG is evaluated in Phase II clinical trials
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Medchemexpress LLC Amine-PEG-amine (MW 5000) | 95.0% | 100 MG
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Amine-PEG-amine (MW 5000) is a PEG-based PROTAC linker utilized in the synthesis of PROTACs. PROTACs are compounds consisting of two distinct ligands connected by a linker; one ligand targets an E3 ubiquitin ligase, and the other targets a protein of interest. This mechanism exploits the intracellular ubiquitin-proteasome system to achieve selective degradation of target proteins. The product is intended for research use only.
- PEG-based PROTAC linker
- Utilized in the synthesis of PROTACs
- Exploits the intracellular ubiquitin-proteasome system to achieve selective degradation of target proteins
- Intended for research use only
- Solid appearance
- White to off-white color
- Molecular weight of 5000 (average)
- 95.0% purity
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Medchemexpress LLC MEDCHEMEXPRESS LLC
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5000338417 IDELALISIB 200MG
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Apexbio Technology LLC Avasimibe 166518-60-1 200mg
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Avasimibe (CAS 166518-60-1) is an orally bioavailable inhibitor of acyl-coenzyme A cholesterol acyltransferase (ACAT) an enzyme involved in cholesterol esterification It exhibits potent inhibition with an IC50 of approximately 60 nM In cell-based studies avasimibe reduces intracellular cholesterol esters in a dose-dependent manner without elevating free cholesterol levels suggesting an advantageous safety profile Additionally avasimibe reduces synthesis and secretion of Apo B 100 a constituent of very low-density lipoprotein (VLDL) in HepG2 cells and increases bile acid synthesis in rat hepatocytes Beyond dyslipidemic modulation and anti-atherogenic activities it influences amyloid precursor protein (APP) trafficking reducing its maturation and subsequent amyloid-beta (A ) peptide generation providing avenues for Alzheimer s disease research
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Sigma Aldrich Fine Chemicals Biosciences Metergoline | 17692-51-2 | MFCD00153829 | 500MG
Metergoline | Mol Wt: 403.52 | 17692-51-2 | MFCD00153829 | 500MG
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Medchemexpress LLC Dihydroergotamine mesylate | 6190-39-2 | 99.9% | 5 MG
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Dihydroergotamine mesylate is a blood-brain barrier (BBB)-permeable ergot alkaloid used in migraine research. It targets 5-HT Receptors within GPCR/G Protein and neuronal signaling pathways.
- Acts as a 5-HT receptor agonist.
- Reduces cell survival in A549 and NCI-H226 cells.
- Inhibits cell survival in Hep3B, PLC/PRF/5, Huh7, and HepG2 cells.
- Induces mitochondrial morphologic alterations and dysfunction.
- Increases reactive oxygen species (ROS) generation.
- Triggers apoptosis and disrupts ATP production.
- Inhibits STAT3 activation and enhances Mcl-1 protein stability.
- Inhibits tumor growth in HepG2 xenografted mice.
- Reduces Ki67 positive cells, Mcl-1, p-Mcl-1, and p-ERK expression.
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Apexbio Technology LLC Tirapazamine(Synonyms: SR-4233, WIN 59075, Tirazone, TPZ, 3-Amino-1,2,4-benzotriazine 1,4-dioxide), 200mg, CAS: 27314-97-2.
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Tirapazamine (CAS 27314-97-2) also known as SR259075 Win59075 or SR4233 is an investigational anticancer agent selectively activated under hypoxic conditions characteristic of solid tumors The compound is bioreduced in hypoxic tumor microenvironments to cytotoxic free radicals leading to cellular damage Tirapazamine downregulates hypoxia-inducible factor-1 (HIF-1 ) thereby influencing pathways associated with tumor adaptive mechanisms to hypoxia Combined treatment with tirapazamine and topoisomerase I inhibitors (such as SN-38 the active metabolite of irinotecan) enhances apoptosis via mitochondria-mediated caspase activation and weakened DNA repair signaling Preclinical investigations including hepatocellular carcinoma xenografts confirm this enhanced tumor suppression Clinical trials evaluating tirapazamine s anticancer efficacy are ongoing
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eMolecules 1677-46-9 | 4-Hydroxy-1-methyl-2-quinolone | Combi-Blocks | MFCD00024052 | 175.187 | C10H9NO2 | 98.000 | Cn1c2ccccc2c(O)cc1=O | 1g | 267209374
4-Hydroxy-1-methyl-2-quinolone | Combi-Blocks | 1677-46-9 | MFCD00024052 | 175.187 | C10H9NO2 | 98.000 | Cn1c2ccccc2c(O)cc1=O | 1g | 267209374
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eMolecules 77156-77-5 | 3-Quinolinecarboxylic acid, 4-hydroxy-6,8-dimethyl-, ethyl ester | MFCD02081544 | 5g
WuXi ChemSupply | 3-Quinolinecarboxylic acid, 4-hydroxy-6,8-dimethyl-, ethyl ester | 5g | 599165295 | LN00179016 | 95.000 | 77156-77-5 | MFCD02081544 | 245.278 | C14H15NO3
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eMolecules 148018-29-5 | 4-Chloro-6-hydroxyquinoline | MFCD00456102 | 250mg
Medchem Express | FKBP12 PROTAC dTAG-7 | 5mg | 515744027 | HY-123941 | 2064175-32-0 | 1210.341 | C63H79N5O19
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Apexbio Technology LLC Sivelestat (ONO-5046) 127373-66-4 200mg
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Sivelestat (ONO-5046) is a selective inhibitor of neutrophil elastase with an IC50 value of 44 nM Neutrophil elastase a serine protease secreted by activated neutrophils can degrade extracellular matrix components and contribute to tissue injury in inflammatory diseases such as rheumatoid arthritis emphysema acute respiratory distress syndrome (ARDS) and septic shock Sivelestat inhibits human neutrophil elastase in a competitive manner and similarly reduces the activity of leukocyte elastases from rodents In animal sepsis models sivelestat attenuates renal dysfunction reduces inflammatory markers like NGAL and increases survival rates Clinically this compound is utilized for managing acute lung injury associated with systemic inflammatory response syndrome and ARDS
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